Ketamine is extremely effective for dealing with daily depression symptoms.
What I found inconvenient is that with habitual use, most patients show a accentuated difficulty in keeping in touch with some social cues.
To illustrate, many patients claimed to have trouble stopping themselves from speaking, making most conversations one sided. It seems like Ketamine stimulates a sort of "neurotic" verbalization. This can be socially crippling for some people, since the listening part is fundamental in social interactions and Ketamine might inhibit the listening part on some patients.
The patient who wants to try Ketamine has to work on self-control and should keep an eye on any unwanted effects.